Research

Powering our research is a suite of open-source software and hardware innovations, which are available via Github. We would be thrilled for you to download, build, and remix our designs!

Generation of Multiscale Vasculature

Gisele Calderon


Gisele joined the Miller lab in 2014 for her Ph.D. work. Her research focuses on generating multiscale vasculature. In particular, she is interested in understanding the appropriate milieu for capillary formation and active angiogenic sprouting within 3D printable biomaterials. The combination of and connection between bottom-up self-assembled microvessels and top-down 3D printed larger vessels might allow for the actualization of multiscale vasculature for engineered tissues. Prior to Miller Lab, Gisele spent a year at the Swiss Federal Institute of Technology in Lausanne, and she received her BSE in Biomedical Engineering from Tulane University in 2013.

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Calderon, Biomaterials Science, 2017

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Long-term perfusion of densely cellularized engineered tissues

Ian Kinstlinger


Ian joined the Miller Lab in 2014 as a bioengineering Ph.D. student. He is interested in answering questions at the intersection of biomaterials, fabrication, and transport phenomena. Earlier in his Ph.D. studies, Ian led the development of a selective laser sintering system which enables the fabrication of complex vascular networks within biocompatible hydrogels through sacrificial templating. Currently, he is focused on using perfusion through engineered vascular networks to support the long-term survival and function of densely cellularized engineered tissues, with an emphasis on the liver. He is also interested in elucidating fundamental design principles linking vascular architecture in engineered tissues to tissue survival and performance. Ian holds a B.S. in Biomedical Engineering from Washington University in St. Louis.


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Gas exchange within entangled vascular networks

Daniel Sazer


Daniel joined the Miller Lab in 2015 as a bioengineering Ph.D. student. Guiding his research is the vision of fully artificial whole organ replacements, deployed directly off the shelf into human patients with end-stage diseases such as heart, lung, and liver failure. He is currently using stereolithography — a light-based 3D printing technique — to build prototype lung mimics containing multiple, independent fluid networks for blood oxygenation. Prior to his time in the Miller Lab, Daniel received his BSE in Biomedical Engineering with a focus on neural tissue engineering. Daniel has also spent time researching immune cell therapy at the Dana-Farber Cancer Institute, and microfluidics fabrication at the Broad Institute.

Pumping and liquid mixing within soft hydrogel tissue mimics

Kevin Janson


Kevin joined the Miller Lab in 2018 as a bioengineering Ph.D. student. Kevin is exploring how soft, compliant hydrogels could be used to promote liquid mixing and pumping, which could increase the viability of artificial lungs. Human lungs are not the best in the animal kingdom—birds, bats, and crocodiles, for example, all have more efficient lung topologies. However, it is possible that by “borrowing” lung features from other animals, we might be able to engineer more efficient lung tissue by promoting gas exchange and blood flow. Before joining the Miller Lab, Kevin received a B.S. in Biomedical Engineering from the University of Virginia